{"id":3149,"date":"2026-04-13T21:39:31","date_gmt":"2026-04-13T13:39:31","guid":{"rendered":"https:\/\/www.atlatl.center\/?page_id=3149"},"modified":"2026-04-22T17:21:38","modified_gmt":"2026-04-22T09:21:38","slug":"drug-screening-center","status":"publish","type":"page","link":"https:\/\/www.atlatl.center\/fr\/platforms\/drug-screening-center\/","title":{"rendered":"Centre de d\u00e9pistage de drogues"},"content":{"rendered":"
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Centre de d\u00e9pistage de drogues<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Le Centre de criblage de m\u00e9dicaments d'ATLATL est con\u00e7u pour aider les \u00e9quipes \u00e0 identifier les mol\u00e9cules d'int\u00e9r\u00eat, \u00e0 valider les cibles et \u00e0 g\u00e9n\u00e9rer plus rapidement des donn\u00e9es de preuve de concept.<\/div>
La plateforme int\u00e8gre l'automatisation, des technologies de d\u00e9tection avanc\u00e9es et des mod\u00e8les biologiquement pertinents dans un environnement d'ex\u00e9cution unique sur site. Les scientifiques peuvent concevoir et ex\u00e9cuter rapidement des exp\u00e9riences avec une configuration minimale, permettant des flux de travail reproductibles \u00e0 haut d\u00e9bit et une it\u00e9ration rapide.<\/div>
En combinant des essais cellulaires, des mod\u00e8les organo\u00efdes, l'imagerie \u00e0 haut contenu et l'analyse mol\u00e9culaire, la plateforme prend en charge des flux de travail de bout en bout, du d\u00e9veloppement et du criblage d'essais \u00e0 la validation des r\u00e9sultats et aux \u00e9tudes du m\u00e9canisme d'action. Situ\u00e9es au sein des bio-hubs d'ATLATL, les \u00e9quipes travaillent c\u00f4te \u00e0 c\u00f4te avec des experts techniques, acc\u00e9l\u00e9rant la prise de d\u00e9cision et r\u00e9duisant le risque de d\u00e9veloppement.<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Capacit\u00e9s de base :<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Criblage \u00e0 haut d\u00e9bit<\/b><\/div>
Criblage automatique de compos\u00e9s pour une identification rapide de hits avec une haute reproductibilit\u00e9.<\/div>
Tests cellulaires et organo\u00efdes<\/b><\/div>
Essais fonctionnels et ph\u00e9notypiques utilisant Syst\u00e8mes cellulaires 2D et mod\u00e8les 3D avanc\u00e9s<\/b>.<\/div>
Validation de la cible et m\u00e9canisme d'action<\/b><\/div>
Analyse mol\u00e9culaire et cellulaire pour confirmer les cibles et comprendre les m\u00e9canismes.<\/div>
Analyse d'Interaction Biomol\u00e9culaire<\/b><\/div>
Analyse de l'affinit\u00e9, de la sp\u00e9cificit\u00e9 et de la cin\u00e9tique de liaison sans marquage, bas\u00e9e sur le SPR.<\/div>
Analyse de donn\u00e9es et progression des r\u00e9ussites<\/b><\/div>
Traitement int\u00e9gr\u00e9 des donn\u00e9es et prise en charge pour s\u00e9lection et optimisation pr\u00e9coces du plomb<\/b>.<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\u00c9quipements :\n<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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ZUOFEI Solution de Manipulation Automatique de Liquides<\/p>

Poste de travail Revvity Janus G3<\/p>

Poste de travail Revvity Zephyr<\/p>

Lecteur de microplaques MD SpectraMax ABS Plus<\/p>

Lecteur de microplaques multimodes MD SpectraMax i3x<\/p>

Lecteur de microplaques Revvity EnVision\u2122<\/p>

Syst\u00e8me d'imagerie \u00e0 haut contenu Revvity Operetta CLS<\/p>

Lecteur de plaques Tecan Spark Cyto<\/p>

Syst\u00e8me PCR en temps r\u00e9el Thermo 7500<\/p>

Syst\u00e8me PCR en temps r\u00e9el Roche LightCycler\u00ae 480<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\"lecteur<\/figure><\/div>
\"lecteur<\/figure><\/div>
\"lecteur<\/figure><\/div>
\"station<\/figure><\/div>
\"Syst\u00e8me<\/figure><\/div>
\"station<\/figure><\/div>
\"syst\u00e8me<\/figure><\/div>
\"lecteur<\/figure><\/div>
\"syst\u00e8me<\/figure><\/div>
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Applications R&D :<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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D\u00e9couverte de petites mol\u00e9cules<\/b><\/p>

Criblage \u00e0 haut d\u00e9bit et profilage dose-r\u00e9ponse<\/p>

Biologique et d\u00e9veloppement d'anticorps<\/b><\/p>

Fixation, puissance et validation fonctionnelle<\/p>

D\u00e9pistage de m\u00e9dicaments oncologiques<\/b><\/p>

Mod\u00e8les tumoraux, syst\u00e8mes de co-culture et organo\u00efdes<\/p>

Immunologie et inflammation<\/b><\/p>

Essais de cellules immunitaires et profilage des cytokines<\/p>

D\u00e9pistage de th\u00e9rapies g\u00e9niques et par ARN<\/b><\/p>

\u00c9valuation des CRISPR, ARNi, ARNm et vecteurs viraux<\/p>

Toxicologie et \u00c9valuation de la S\u00e9curit\u00e9<\/b><\/p>

D\u00e9tection pr\u00e9coce de la cytotoxicit\u00e9 et des effets hors cible<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Drug Screening Center The Drug Screening Center at ATLATL is built to help teams identify hits, validate targets, and generate proof-of-concept data faster.The platform integrates automation, advanced detection technologies, and biologically relevant models into a single, on-site execution environment. Scientists […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":752,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","site-sidebar-layout":"left-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"normal-width-container","site-content-style":"default","site-sidebar-style":"boxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"659","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-3149","page","type-page","status-publish"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/pages\/3149","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/comments?post=3149"}],"version-history":[{"count":10,"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/pages\/3149\/revisions"}],"predecessor-version":[{"id":3976,"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/pages\/3149\/revisions\/3976"}],"up":[{"embeddable":true,"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/pages\/752"}],"wp:attachment":[{"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/media?parent=3149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}