{"id":3143,"date":"2026-04-13T21:37:58","date_gmt":"2026-04-13T13:37:58","guid":{"rendered":"https:\/\/www.atlatl.center\/?page_id=3143"},"modified":"2026-04-22T17:20:09","modified_gmt":"2026-04-22T09:20:09","slug":"cell-gene-therapy-center","status":"publish","type":"page","link":"https:\/\/www.atlatl.center\/fr\/platforms\/cell-gene-therapy-center\/","title":{"rendered":"Centre de th\u00e9rapies cellulaires et g\u00e9niques"},"content":{"rendered":"
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Centre de th\u00e9rapies cellulaires et g\u00e9niques<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Le Centre de th\u00e9rapies cellulaires et g\u00e9niques d'ATLATL est con\u00e7u pour aider les \u00e9quipes \u00e0 concevoir, d\u00e9velopper et faire progresser les th\u00e9rapies cellulaires et g\u00e9niques, du concept \u00e0 la pr\u00e9paration pr\u00e9clinique, plus rapidement.<\/div>
\u00a0<\/div>
La plateforme int\u00e8gre l'ing\u00e9nierie cellulaire, le g\u00e9nie g\u00e9n\u00e9tique, le d\u00e9veloppement de vecteurs viraux, l'optimisation des processus et les capacit\u00e9s analytiques dans un environnement d'ex\u00e9cution unique et sur site. Les scientifiques travaillent c\u00f4te \u00e0 c\u00f4te avec des experts techniques, permettant ainsi des it\u00e9rations en temps r\u00e9el, une r\u00e9solution rapide des probl\u00e8mes et une g\u00e9n\u00e9ration efficace de donn\u00e9es de preuve de concept.<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Capacit\u00e9s de base :<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Ing\u00e9nierie cellulaire et \u00e9dition g\u00e9nique<\/b><\/div>
\u00c9dition bas\u00e9e sur CRISPR, transduction virale et d\u00e9veloppement de mod\u00e8les cellulaires personnalis\u00e9s pour la conception et la validation th\u00e9rapeutiques.<\/div>
D\u00e9veloppement de proc\u00e9d\u00e9s de th\u00e9rapie cellulaire<\/b><\/div>
Optimisation de l'expansion, de l'activation et de la diff\u00e9renciation des cellules T, des cellules souches et d'autres types de cellules th\u00e9rapeutiques.<\/div>
G\u00e8ne de d\u00e9livrance et d\u00e9veloppement de vecteur<\/b><\/div>
D\u00e9veloppement et \u00e9valuation de syst\u00e8mes de livraison viraux (lentivirus, AAV) et non viraux.<\/div>
Tests Fonctionnels et de Puissance<\/b><\/div>
Cytom\u00e9trie en flux, dosages de cytotoxicit\u00e9 et profilage des cytokines pour \u00e9valuer l'activit\u00e9 th\u00e9rapeutique.<\/div>
Contr\u00f4le Qualit\u00e9 & Caract\u00e9risation<\/b><\/div>
Tests d'identit\u00e9, de puret\u00e9, de viabilit\u00e9 et de s\u00e9curit\u00e9 pour garantir des flux de travail robustes et reproductibles.<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\u00c9quipements :<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Syst\u00e8me Bio-Rad Gel Doc\u2122 EZ<\/p>

Bio-Rad Gene Pulser Xcell<\/p>

Syst\u00e8me Bio-Rad QX200 AutoDG Droplet Digital PCR<\/p>

Thermocycleur Bio-Rad T100<\/p>

Syst\u00e8me d'\u00e9lectroporation cellulaire Celetrix LE<\/p>

Microscope invers\u00e9 \u00e0 lumi\u00e8re transmise num\u00e9rique Leica Mateo TL<\/p>

Compteur de cellules fluorescentes Revvity Cellometer K2<\/p>

Miltenyi Biotec gentle MACS\u2122 Octo Dissociator avec Chauffage<\/p>

Compteur de cellules automatis\u00e9 Thermo Countess 3<\/p>

Spectrophotom\u00e8tre Thermo NanoDrop\u2122 OneC<\/p>

Thermo SimpliAmp\u2122 Thermocycleur<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\"thermo<\/figure><\/div>
\"spectrophotom\u00e8tre<\/figure><\/div>
\"thermo<\/figure><\/div>
\"Compteur<\/figure><\/div>
\"Miltenyi<\/figure><\/div>
\"microscope<\/figure><\/div>
\"le<\/figure><\/div>
\"thermo-cycler<\/figure><\/div>
\"syst\u00e8me<\/figure><\/div>
\"bio<\/figure><\/div>
\"syst\u00e8me<\/figure><\/div>\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t
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<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Applications R&D :<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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D\u00e9veloppement CAR-T \/ TCR-T<\/b><\/p>

Conception, ing\u00e9nierie et validation des th\u00e9rapies par cellules immunitaires<\/span><\/p>

Modification g\u00e9n\u00e9tique et g\u00e9nomique fonctionnelle<\/b><\/p>

Mod\u00e8les de d\u00e9l\u00e9tion\/d'insertion g\u00e9nique et validation de voies de signalisation<\/span><\/p>

Cellules souches et programmes de cellules souches pluripotentes induites<\/b><\/div>
Diff\u00e9renciation, mod\u00e9lisation de maladies et applications r\u00e9g\u00e9n\u00e9ratives<\/span><\/div><\/div>

D\u00e9veloppement de vecteurs viraux<\/b><\/p>

Production, purification et titrage de lentivirus et d'AAV<\/div><\/div>

\u00c9valuation pr\u00e9clinique<\/b><\/p>

Mod\u00e8les in vitro et ex vivo, y compris les syst\u00e8mes de co-culture et d'organo\u00efdes<\/div><\/div>

Mont\u00e9e en \u00e9chelle des proc\u00e9d\u00e9s et transfert de technologie<\/b><\/p>

Transition de la recherche \u00e0 la production pilote<\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Cell & Gene Therapy Center The Cell & Gene Therapy Center at ATLATL is built to help teams design, develop, and advance cell and gene therapies from concept to preclinical readiness faster.\u00a0The platform integrates cell engineering, gene editing, viral vector […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":752,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","site-sidebar-layout":"left-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"normal-width-container","site-content-style":"default","site-sidebar-style":"boxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"659","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-3143","page","type-page","status-publish"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/pages\/3143","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/comments?post=3143"}],"version-history":[{"count":10,"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/pages\/3143\/revisions"}],"predecessor-version":[{"id":3973,"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/pages\/3143\/revisions\/3973"}],"up":[{"embeddable":true,"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/pages\/752"}],"wp:attachment":[{"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/media?parent=3143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}