{"id":3139,"date":"2026-04-13T21:37:03","date_gmt":"2026-04-13T13:37:03","guid":{"rendered":"https:\/\/www.atlatl.center\/?page_id=3139"},"modified":"2026-04-22T17:23:40","modified_gmt":"2026-04-22T09:23:40","slug":"exosome-ev-center","status":"publish","type":"page","link":"https:\/\/www.atlatl.center\/fr\/platforms\/exosome-ev-center\/","title":{"rendered":"Centre des exosomes et des VEs"},"content":{"rendered":"
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Centre des exosomes et des EV<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Le Centre Exosome & EV d'ATLATL est con\u00e7u pour aider les \u00e9quipes \u00e0 d\u00e9velopper et valider plus rapidement des th\u00e9rapeutiques et des syst\u00e8mes de d\u00e9livrance bas\u00e9s sur les exosomes.<\/p>

Les exosomes offrent une approche prometteuse pour les th\u00e9rapies sans cellules et la d\u00e9livrance cibl\u00e9e, avec des avantages en termes de biocompatibilit\u00e9, de stabilit\u00e9 et de p\u00e9n\u00e9tration tissulaire (y compris la barri\u00e8re h\u00e9mato-enc\u00e9phalique). Chez ATLATL, nous fournissons une plateforme int\u00e9gr\u00e9e de bout en bout couvrant l'isolement, la caract\u00e9risation, la validation fonctionnelle et la production \u00e0 grande \u00e9chelle.<\/p>

Install\u00e9s au sein de nos bio-hubs, les scientifiques travaillent aux c\u00f4t\u00e9s d'experts techniques, permettant une it\u00e9ration rapide et la g\u00e9n\u00e9ration de donn\u00e9es d\u00e9cisionnelles, de la recherche initiale au d\u00e9veloppement translationnel.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Capacit\u00e9s cl\u00e9s :<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Isolation et purification<\/strong><\/p>

Isolation automatis\u00e9e \u00e0 haut rendement \u00e0 partir de divers types d'\u00e9chantillons (cultures cellulaires, plasma, urine, etc.), garantissant une grande puret\u00e9, un rendement \u00e9lev\u00e9 et une bioactivit\u00e9 pr\u00e9serv\u00e9e.<\/p>

Caract\u00e9risation et contr\u00f4le qualit\u00e9<\/strong><\/p>

Analyse compl\u00e8te incluant :<\/p>

\u2022 Taille et concentration (NTA)<\/p>

\u2022Morphologie (MET \/ Cryo-MET)<\/p>

\u2022 Marqueurs de surface (FACS, WB, NanoFCM)<\/p>

\u2022 Stabilit\u00e9 et charge (potentiel Z\u00eata)<\/p>

Validation fonctionnelle<\/strong><\/p>

\u00c9valuation de l'activit\u00e9 biologique \u00e0 l'aide de mod\u00e8les cellulaires et in vivo<\/strong>, \u00e9tay\u00e9e par des \u00e9tudes multiomiques et m\u00e9canistiques.<\/p>

Ing\u00e9nierie et d\u00e9veloppement th\u00e9rapeutique<\/strong><\/p>

Soutien pour chargement de m\u00e9dicament, modification du ciblage et marquage<\/strong>, permettant le d\u00e9veloppement de syst\u00e8mes de d\u00e9livrance \u00e0 base d'exosomes.<\/p>

Support de mise \u00e0 l'\u00e9chelle et de fabrication<\/strong><\/p>

De la recherche \u00e0 petite \u00e9chelle \u00e0 pilote et production \u00e0 grande \u00e9chelle<\/strong>, avec des flux de travail con\u00e7us pour la coh\u00e9rence et la reproductibilit\u00e9.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\u00c9quipements :\n<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Syst\u00e8me d'imagerie Bio-Rad ChemiDoc MP<\/p>

Microscope \u00e9lectronique en transmission FEI Tecnai G2 T12<\/p>

Syst\u00e8me d'isolement d'exosomes automatique HUIXIN EXODUS H-2800<\/p>

SYST\u00c8ME D'ISOLEMENT AUTOMATIQUE D'EXOSOMES HUIXIN EXODUS H-600<\/p>

SYST\u00c8ME D'ISOLEMENT D'EXOSOMES AUTOMATIQUE HUIXIN EXODUS H300<\/p>

Miltenyi Biotec MACSQuant\u00ae Analyzer 16<\/p>

NanoFCM Cytom\u00e9trie en flux nano<\/p>

Nikon Microscope confocal \u00e0 balayage laser AX<\/p>

Analyseur de particules PARTICLE METRIX ZETAVIEW<\/p>

Analyseur de particules Resuntech NanoCoulter<\/p>

Thermo iBind\u2122 Flex Western<\/p>

Syst\u00e8me de transfert Thermo iBlot 3<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\"syst\u00e8me<\/figure><\/div>
\"microscope<\/figure><\/div>
\"syst\u00e8me<\/figure><\/div>
\"syst\u00e8me<\/figure><\/div>
\"Syst\u00e8me<\/figure><\/div>
\"Analyseur<\/figure><\/div>
\"nanofcm<\/figure><\/div>
\"microscope<\/figure><\/div>
\"Analyseur<\/figure><\/div>
\"Analyseur<\/figure><\/div>
\"thermo<\/figure><\/div>
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Applications R&D :<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Plateformes de lib\u00e9ration de m\u00e9dicaments<\/strong><\/p>

Administration par exosomes pour les ARN, les prot\u00e9ines et les petites mol\u00e9cules<\/p>

Th\u00e9rapies sans cellules<\/strong><\/p>

Exosomes d\u00e9riv\u00e9s de cellules souches pour des applications r\u00e9g\u00e9n\u00e9ratives et immunomodulatrices<\/p>

D\u00e9couverte de biomarqueurs<\/strong><\/p>

Biopsie liquide et surveillance de la maladie<\/p>

Validation et \u00e9tudes m\u00e9canistiques de la cible<\/strong><\/p>

Analyse fonctionnelle et multi-omique<\/p>

D\u00e9veloppement Translationnel<\/strong><\/p>

La transition de la recherche \u00e0 la validation pr\u00e9clinique et clinique pr\u00e9coce<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Exosome & EV Center The Exosome & EV\u00a0Center at ATLATL is designed to help teams develop and validate exosome-based therapeutics and delivery systems faster. Exosomes offer a promising approach for cell-free therapies and targeted delivery, with advantages in biocompatibility, stability, and […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":752,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","site-sidebar-layout":"left-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"normal-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-3139","page","type-page","status-publish"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/pages\/3139","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/comments?post=3139"}],"version-history":[{"count":10,"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/pages\/3139\/revisions"}],"predecessor-version":[{"id":3980,"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/pages\/3139\/revisions\/3980"}],"up":[{"embeddable":true,"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/pages\/752"}],"wp:attachment":[{"href":"https:\/\/www.atlatl.center\/fr\/wp-json\/wp\/v2\/media?parent=3139"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}